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In the absence of intracel-lular nucleophiles such as GSH, this reactive metabolite ( N -acetylbenzoiminoquinone) reacts with nucleophilic groups of cellular proteins, resulting in hepatotoxicity.The chemical and toxicologic characterization of the electro-philic nature of the reactive acetaminophen metabolite has led to the development of effective antidotescysteamine and N -acetylcysteine

2 REIMAGINE 3 was a 40-week phase 3 trial evaluating the safety and efficacy of CagriSema 2.4 mg/2.4 mg and 1 mg/1 mg once weekly versus dose-matched placebo in 274 adults with T2D as add-on to once-daily basal insulin with or without metformin

Interleukin-6 (IL-6), tumor necrosis factor- (TNF-), nuclear factor erythroid 2-related factor 2 (NRF2), nuclear factor-B/P65 (NF-B/P65), superoxide dismutase type 1 (SOD1), caspase-1 (Casp-1), AQP1, AQP2, and kidney injury molecule-1 (KIM-1) were the primers used in the PCR that was conducted using a thermal cycler (A200 Gradient Thermal Cycler, LongGene , Hangzhou, China) (Supplementary Table S1)

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